Sermorelin Reconstitution & Dosage Calculator
A GHRH receptor agonist studied for stimulating the body's own pulsatile growth hormone release.
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How to reconstitute Sermorelin
Sermorelin reconstitutes to a set concentration. Add 2 mL of bacteriostatic water to a 5 mg vial for a 2.5 mg/mL solution.
Mixing is one decision: how much bacteriostatic water goes in. Dosing follows from it, and the syringe reads the result. The instructions below are the whole procedure.
| Vial size | BAC water | Concentration | 250 mcg draws to |
|---|---|---|---|
| 5 mg | 2 mL | 2.5 mg/mL | 10 units |
| 10 mg | 4 mL | 2.5 mg/mL | 10 units |
Units are shown for a U-100 insulin syringe. A common starting dose is 250 mcg. At 2.5 mg/mL, that draws to 10 units on a U-100 insulin syringe.
How Sermorelin works
Binds GHRH receptors in the anterior pituitary to trigger natural pulsatile growth hormone secretion and downstream IGF-1 production. It enhances endogenous output rather than supplying hormone directly.
Reported side effects
- Temporary flushing
- Dizziness
- Injection site irritation
When is Sermorelin taken?
Sermorelin is commonly taken in the evening.
Reconstituting Sermorelin, step by step
Reconstituting is the mixing step: bacteriostatic water goes into the vial of lyophilized powder, and the powder becomes a solution a syringe can measure. For a 5 mg vial of Sermorelin the calculator's water volume is 2 mL, which gives 2.5 mg/mL. The technique is the same for every peptide; only the water volume changes.
- Prep. Remove the plastic caps from the Sermorelin vial and the bacteriostatic water vial. Wipe both rubber stoppers with an alcohol pad and let them air dry for about ten seconds.
- Equalize the pressure. Pull 2 mL of air into the mixing syringe and push it into the water vial. The positive pressure makes the draw easier.
- Draw the water. Turn the water vial upside down and draw 2 mL.
- Inject down the glass. Put the needle through the center of the Sermorelin stopper, aim the tip at the inside wall, and press slowly so the water runs down the glass instead of hitting the powder. Peptides are fragile chains, and a jet of water straight onto the powder can damage them.
- Swirl, never shake. Withdraw the syringe and roll the vial in slow circles until the solution is clear.
The reasoning behind each step is in the guide Peptide reconstitution is one number. Bacteriostatic water, not sterile water, is what makes a multi-draw vial possible; the difference, and the 28-day question, is in bacteriostatic vs sterile water.
Dilution: the water volume sets the units
Two numbers decide everything on the syringe. Concentration is the vial's mg divided by the water added, and the draw is the dose divided by that concentration, read as units on a U-100 insulin syringe, where 1 mL is 100 units. Diluting a vial with more water does not change the amount of Sermorelin in it; it spreads the same 5 mg across more liquid, so every dose becomes a larger draw. Less water does the opposite.
| Water added to 5 mg | Concentration | 250 mcg draws to |
|---|---|---|
| 1 mL | 5 mg/mL | 5 units |
| 2 mL (the standard) | 2.5 mg/mL | 10 units |
| 4 mL | 1.25 mg/mL | 20 units |
The standard row is what the calculator uses for this vial. The other rows show the arithmetic, not a recommendation. The dose is entered in the calculator, never read off a table.
How many vials a 10 mL bottle of bacteriostatic water mixes
Bacteriostatic water is sold in 10 mL and 30 mL bottles. At 2 mL per 5 mg vial of Sermorelin, a 10 mL bottle reconstitutes 5 vials, and a 30 mL bottle reconstitutes 15. The 0.9% benzyl alcohol preservative is what lets one bottle serve several vials over several weeks. What a milligram costs right now across the stores TR8CE tracks is on the peptide price index.
| Vial size | Water per vial | Vials per 10 mL bottle | Vials per 30 mL bottle |
|---|---|---|---|
| 5 mg | 2 mL | 5 | 15 |
| 10 mg | 4 mL | 2 | 7 |
Sermorelin in units on a U-100 syringe
At 2.5 mg/mL, every 1 mg is 40 units. The rows below are the conversion at the calculator's standard concentration, up to one full 100-unit syringe. A vial size not listed follows the same rule: water equals size divided by 2.5. A 2 mg Sermorelin vial follows the same rule at 2.5 mg/mL: 0.8 mL of water, and 250 mcg still draws to 10 units.
| Amount of Sermorelin | U-100 syringe |
|---|---|
| 50 mcg | 2 units |
| 100 mcg | 4 units |
| 200 mcg | 8 units |
| 250 mcg (the COMMON reference) | 10 units |
| 500 mcg | 20 units |
| 2500 mcg | 100 units |
Storage after reconstituting
Once mixed, a Sermorelin vial is kept refrigerated at 36 to 46 °F (2 to 8 °C) and is not frozen. TR8CE's vault uses a common 28-day refrigerated use-by window as general research guidance, not medical advice. Most peptides reconstitute clear, and a solution that stays cloudy or shows particles after a few minutes of gentle swirling may be degraded or low purity, which is exactly the question a certificate of analysis answers before the vial is ever opened.
Frequently asked
How much bacteriostatic water do I add to Sermorelin?
Add 2 mL of bacteriostatic water to a 5 mg Sermorelin vial for a 2.5 mg/mL solution.
What is a common Sermorelin dose?
A common Sermorelin starting dose is 250 mcg, which at 2.5 mg/mL draws to 10 units on a U-100 insulin syringe.
How do you reconstitute Sermorelin?
Draw bacteriostatic water into a syringe, inject it slowly down the inside glass of the Sermorelin vial (not onto the powder), and swirl gently until clear. Store refrigerated and use within the common window.
How do you reconstitute a 5 mg Sermorelin vial?
Add 2 mL of bacteriostatic water to a 5 mg Sermorelin vial for a 2.5 mg/mL solution. A 250 mcg dose then draws to 10 units on a U-100 insulin syringe.
How do you reconstitute a 10 mg Sermorelin vial?
Add 4 mL of bacteriostatic water to a 10 mg Sermorelin vial for a 2.5 mg/mL solution. A 250 mcg dose then draws to 10 units on a U-100 insulin syringe.
How many vials of Sermorelin does a 10 mL bottle of bacteriostatic water reconstitute?
At 2 mL per 5 mg vial, a 10 mL bottle of bacteriostatic water reconstitutes 5 vials, and a 30 mL bottle reconstitutes 15.
What happens if you add more water when reconstituting Sermorelin?
The amount of Sermorelin in the vial does not change; the concentration falls and each dose becomes a larger draw. 5 mg in 2 mL is 2.5 mg/mL, so 250 mcg draws to 10 units; in 4 mL it is 1.25 mg/mL and the same 250 mcg draws to 20 units.
How is reconstituted Sermorelin stored?
Refrigerated at 36 to 46 °F (2 to 8 °C), never frozen, with a common 28-day refrigerated use-by window as general research guidance, not medical advice.
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